Phase II Clinical Trials May Be on the Way for Ovarian Cancer - NFCR


Phase II Clinical Trials May Be on the Way for Ovarian Cancer

New Ovarian Cancer Treatment May Be On the Way

Dubbed one of the notorious ‘silent killers’, ovarian cancer claims the lives of approximately 14,000 American women each year. Tragically, all women are at risk and early detection and sustainable treatment have proved to be difficult. However, a recent study provides new hope in the realm of ovarian cancer treatment.

Women who are diagnosed with ovarian cancer are commonly prescribed two chemotherapy drugs: paclitaxel and carboplatin. When a patient’s body resists these drugs, she is left with few options for continued ovarian cancer treatment. For those who do not experience initial resistance, the looming threat of recurrence suggests future difficulties.

Thankfully, the ominous outlook for ovarian cancer treatment is looking brighter thanks to physician-scientist Robert C Bast, Jr, MD., and his past support from the National Foundation for Cancer Research (NFCR).  Acknowledging early funding from the NFCR, Dr. Bast has recently published his research results that provide substantial hope for women undergoing ovarian cancer treatment.

In this study Dr. Bast explains that while carboplatin and paclitaxel can be a strong first-line treatment for ovarian cancer, the drugs are curing less than 20% of advanced stage ovarian cancer.

However, a small molecule inhibitor can improve the response to paclitaxel in ovarian cancer cells and complex models during the pre-clinical research and the combined treatment is being used now in a Phase I trial for ovarian cancer. In the current paper, the research team discovered that the inhibitor increased carboplatin’s ability to induce DNA-damage and apoptosis (cell suicide), simply meaning the drug’s ability to kill cancerous cells improved.

Dr. Bast continues to explain that discovering the impact of the molecular inhibitor on carboplatin provides an exciting outlook for upcoming clinical trials for ovarian cancer treatment.

If the ongoing Phase I trial treating ovarian cancer patients with the combination of paclitaxel and the inhibitor goes well, a Phase I/II trial may be initiated using the molecule inhibitor and carboplatin.

This exciting discovery suggests that women undergoing ovarian cancer treatment may have a more promising outlook, especially those who experience resistance to carboplatin and paclitaxel or have a recurrence of ovarian cancer.

NFCR continues to support world leaders in ovarian cancer research. Amongst these current and past funded scientists are Dr. Danny Welch, Dr. Wei Zhang, Dr. Susan Horwitz, Dr. Amos B. Smith III, and Dr. Harold F. Dvorak. Each dedicated NFCR-funded researcher is committed to game-changing discoveries in cancer treatments, detection, and ultimately, a cure.

Visit National Foundation for Cancer Research to learn how you can play a role in supporting world leaders in cancer research.

Additional Reads You May Enjoy:

Genetic Cues to Ovarian Cancer Explored

The Development of Better Ovarian Cancer Biomarkers

5 Warning Signs Women Shouldn’t Ignore

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  1. REPLY
    Olateju Fagbeja says

    Hello, My sister was recently diagnosed with a rare form of aggressive ovarian cancer – a carcinosarcoma and was staged as 3b. She underwent surgery and is being prepped to commence chemotherapy. I would be glad if you could provide any information on how she can participate in a relevant clinical trial. She is based in the UK. Thank you.

  2. REPLY
    Linda Scott says

    I have stage 4 ovarian cancer, high grade serous adenocarcinoma, which my oncologist has deemed inoperative. I am on chemotherapy of Paclitaxel and Carboplatin of which I have currently received 7 cycles, out of 8 which were recommended and have received 3 cycles of Avastin which my oncologist has recommended to be on-going. Although I am resident in the UK, I would be grateful to receive any information or recommendations regarding clinical trials, or relevant information you would be able to offer. Many thanks, and I wish you continued success.

  3. REPLY
    Cindy M. David says

    Hi I have stage IIIc high grade serous ovarian cancer, first diagnosed in April 2018, debulking followed by chemo , then first recurrence in May 2020, 2nd line chemo plus Zejula as maintenance. Just having another recurrence – will be treated with radiology with more chemo. Based in BC in Canada and would be interested in joining any clinical trial

  4. REPLY
    Magda says

    I was diagnosed with 4 stage ovarian cancer in October 2020.
    Had debulking surgery, chemotherapy, now on Zejula for 3 months.
    Living in BC Canada and would be interested to join any trial .

  5. REPLY
    Magda says

    Thank you for your time to answer my request.

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